Involvement of αvβ3 integrin in gremlin-induced angiogenesis
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چکیده
منابع مشابه
Involvement of integrin áíâ3 in thrombin-induced angiogenesis
Thrombin was reported to be a potent angiogenic factor both in vitro and in vivo and many of the cellular effects of thrombin may contribute to activation of angiogenesis. In this report we show that thrombin-treatment of human endothelial cells increases mRNA and protein levels of ανβ3 integrin. This thrombin-mediated effect is specific, dose-dependent and requires the catalytic site of thromb...
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The alphavbeta3 integrin plays a fundamental role during the angiogenesis process by inhibiting endothelial cell apoptosis. However, the mechanism of inhibition is unknown. In this report, we show that integrin-mediated cell survival involves regulation of nuclear factor-kappa B (NF-kappaB) activity. Different extracellular matrix molecules were able to protect rat aorta- derived endothelial ce...
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Tsopanoglou, Nikos E., Paraskevi Andriopoulou, and Michael E. Maragoudakis. On the mechanism of thrombin-induced angiogenesis: involvement of v 3-integrin. Am J Physiol Cell Physiol 283: C1501–C1510, 2002. First published July 17, 2002; 10.1152/ajpcell.00162.2002.— Thrombin has been reported to be a potent angiogenic factor both in vitro and in vivo, and many of the cellular effects of thrombin...
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ژورنال
عنوان ژورنال: Angiogenesis
سال: 2012
ISSN: 0969-6970,1573-7209
DOI: 10.1007/s10456-012-9309-6